Written by The HG Collective · Reviewed by HG Clinicians Expert Panel · Last reviewed: July 2026
Pregnancy sickness and HG: symptoms and diagnosis
Nausea and vomiting in pregnancy are common and can vary considerably in severity. Symptoms usually begin early in pregnancy and, for most people, improve by 20 weeks. Hyperemesis gravidarum (HG) is the severe end of this spectrum. It can prevent someone from eating and drinking normally, severely restrict everyday life and lead to dehydration, weight loss and nutritional problems.
You do not have to be vomiting to have HG. Under the internationally agreed Windsor Definition, severe nausea alone can meet the definition when it prevents normal eating or drinking and strongly limits daily activities.
You also do not need to wait until you are dehydrated, losing weight or unable to keep anything down before asking for help. Symptoms that do not meet every criterion for HG may still need treatment.
How does pregnancy sickness differ from HG?
Pregnancy sickness is common. It often begins between 4 and 7 weeks of pregnancy, is usually worst at around 9 weeks and improves by 20 weeks for most people.
HG is more severe. The Windsor Definition describes HG as:
- symptoms beginning before 16 weeks of pregnancy;
- severe nausea and/or vomiting;
- being unable to eat and/or drink normally; and
- symptoms that strongly limit daily activities.
Signs of dehydration can support the diagnosis, but they are not required. Neither is a particular amount of vomiting. Severe nausea without frequent vomiting can still be HG.
“Beginning before 16 weeks” refers to when the symptoms start. HG can continue beyond 16 or 20 weeks and, for some people, lasts until birth. If nausea or vomiting starts for the first time at or after 16 weeks, your healthcare team should consider other possible causes.
The Windsor Definition was developed through an international consensus process involving patients, clinicians and researchers. Its four mandatory features are onset before 16 weeks, severe nausea and/or vomiting, inability to eat and/or drink normally, and symptoms that strongly limit daily activities. Signs of dehydration are contributory rather than mandatory.[1]
RCOG's 2024 Green-top Guideline incorporates the Windsor Definition. It describes nausea and vomiting of pregnancy as a spectrum, with HG at the severe end, and notes that pregnancy sickness usually starts between 4 and 7 weeks, peaks at approximately 9 weeks and resolves by 20 weeks in 90% of women. It also advises that other causes should be investigated when symptoms begin at or after 16 weeks.[2]
A prospective community study found that symptoms sometimes continued beyond 20 weeks and, in a small proportion of pregnancies, until birth.[3]
References
- [1] Jansen LAW, Koot MH, van't Hooft J, et al. The Windsor definition for hyperemesis gravidarum: a multistakeholder international consensus definition. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2021;266:15–22. https://doi.org/10.1016/j.ejogrb.2021.09.004
- [2] Nelson-Piercy C, Dean C, Shehmar M, et al. The management of nausea and vomiting in pregnancy and hyperemesis gravidarum: Green-top Guideline No. 69. BJOG. 2024. https://doi.org/10.1111/1471-0528.17739
- [3] Gadsby R, Barnie-Adshead AM, Jagger C. A prospective study of nausea and vomiting during pregnancy. British Journal of General Practice. 1993;43(371):245–248. https://pubmed.ncbi.nlm.nih.gov/8373648/
What signs and symptoms should I look out for?
HG does not look exactly the same for everyone. Possible signs include:
- severe or prolonged nausea, even if you are not vomiting;
- repeated vomiting or retching;
- difficulty eating or drinking normally;
- being unable to keep down fluids, food or medication;
- losing weight;
- excessive saliva or needing to spit frequently;
- feeling very weak, exhausted, dizzy or lightheaded;
- passing much less urine than usual, or urine that is dark yellow and strong-smelling;
- a dry mouth or lips, intense thirst or other signs of dehydration; and
- symptoms that make ordinary activities—such as washing, working, caring for others or leaving bed—very difficult or impossible.
You do not need to have every symptom on this list, and vomiting frequency alone does not show how unwell you are.
The Windsor Definition deliberately uses “nausea and/or vomiting”. Severe nausea can therefore satisfy this part of the definition even when vomiting is absent or infrequent. The definition also places the ability to eat and drink, and the effect on daily activities, at the centre of diagnosis.[1]
RCOG recommends assessing symptoms and their effect on quality of life, oral intake, weight and hydration. Its assessment framework includes nausea, vomiting, retching, excessive salivation, inability to tolerate food or fluids, weight loss, dizziness, reduced urine output, dry mucous membranes, low blood pressure and increased heart rate.[2]
NHS guidance lists thirst, tiredness, dizziness or lightheadedness, reduced urination, and dark yellow, strong-smelling urine among signs of dehydration.[3]
References
- [1] Jansen LAW, Koot MH, van't Hooft J, et al. The Windsor definition for hyperemesis gravidarum: a multistakeholder international consensus definition. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2021;266:15–22. https://doi.org/10.1016/j.ejogrb.2021.09.004
- [2] Nelson-Piercy C, Dean C, Shehmar M, et al. The management of nausea and vomiting in pregnancy and hyperemesis gravidarum: Green-top Guideline No. 69. BJOG. 2024. https://doi.org/10.1111/1471-0528.17739
- [3] NHS. Severe vomiting in pregnancy. https://www.nhs.uk/pregnancy/complications/severe-vomiting/
When should I ask for help?
Contact your GP, midwife, maternity unit or early pregnancy service promptly if nausea or vomiting is making it difficult to eat, drink, take medication or manage normal daily activities. Ask for help if you are losing weight or have signs of dehydration, including dizziness, intense thirst, a dry mouth, very dark urine or passing much less urine than usual.
Seek urgent medical advice if you cannot keep fluids or essential medication down, are passing very little or no urine, feel faint or seriously unwell, or have another health condition—such as diabetes or epilepsy—that could become unsafe when you cannot eat, drink or take medication normally.
You do not need to wait for symptoms to become an emergency. You also do not need to wait for a urine test to show ketones before treatment can be offered.
RCOG recommends community treatment when a person is not dehydrated, and escalation to ambulatory or inpatient care according to clinical need. Reasons to consider inpatient care include inability to keep down oral anti-sickness medication, clinical dehydration, weight loss of more than 5% despite oral treatment, a suspected or confirmed accompanying condition, or a medical condition made unsafe by an inability to tolerate food, fluids or essential medication.[1]
RCOG states that ketonuria is not an indicator of dehydration and must not be used to assess severity. A person should therefore not have to demonstrate urinary ketones before receiving assessment or treatment.[1]
References
- [1] Nelson-Piercy C, Dean C, Shehmar M, et al. The management of nausea and vomiting in pregnancy and hyperemesis gravidarum: Green-top Guideline No. 69. BJOG. 2024. https://doi.org/10.1111/1471-0528.17739
- [2] NHS. Severe vomiting in pregnancy. https://www.nhs.uk/pregnancy/complications/severe-vomiting/
How is HG diagnosed?
There is no single blood test, urine test or scan that proves whether someone has HG. Diagnosis is based on your symptoms and a clinical assessment, using the Windsor Definition and ruling out other possible causes.
Your healthcare professional may ask about:
- when your symptoms began;
- the severity of nausea, vomiting and retching;
- what you can eat and drink, and whether you can keep medication down;
- weight loss and signs of dehydration;
- the effect on daily life and emotional wellbeing;
- previous pregnancies with HG; and
- other symptoms or medical conditions that could suggest a different or additional cause.
They may check your weight, pulse, blood pressure, temperature and hydration. Urine and blood tests may be used to look for complications or other conditions, and an ultrasound may be offered when clinically indicated—for example, to confirm the pregnancy or check for multiple pregnancy. These investigations support safe care; they are not a test of whether your symptoms are real.
What about urine ketones?
A urine sample can still be useful—for example, to look for signs of a urinary tract infection. What has changed is the use of ketones. Current RCOG guidance says ketones in urine do not reliably show dehydration or the severity of HG. They should not be used to diagnose HG, decide how unwell you are, determine whether you need admission or delay treatment.
How is severity measured?
Your team may use a symptom questionnaire to record severity and response to treatment. The Pregnancy-Unique Quantification of Emesis (PUQE) score can help assess mild-to-moderate pregnancy sickness, but it has not been validated for severe HG. The HyperEmesis Level Prediction (HELP) score includes a wider range of symptoms and has been validated across the full spectrum, including severe disease. Neither score replaces clinical judgement or the Windsor Definition.
RCOG describes NVP and HG as clinical diagnoses. Its recommended assessment covers history, examination, weight and hydration, with investigations selected to identify complications and exclude other causes. These may include urinalysis for infection, urine culture when indicated, urea and electrolytes, a full blood count and glucose. Further tests—such as thyroid or liver function tests, calcium, phosphate, amylase or blood gas analysis—may be appropriate in refractory cases or after previous admissions. Ultrasound is used when clinically indicated rather than as a diagnostic test for HG.[1]
Abnormal thyroid blood results are common in HG and are usually a temporary biochemical effect of pregnancy sickness. RCOG advises against antithyroid treatment for gestational transient thyrotoxicosis; clinical context and appropriate follow-up are important.[1]
RCOG gives a Grade A recommendation that ketonuria is not an indicator of dehydration and should not be used to assess severity.[1] A systematic review found no single biomarker sufficiently reliable for diagnosing HG,[2] and a prospective cohort study found no association between the degree of ketonuria and HG disease severity.[3]
RCOG recommends validated symptom tools, while explaining their different uses: PUQE is validated for mild-to-moderate NVP but not severe NVP/HG, whereas HELP has been validated for all severities and can help follow change over time.[1] Validation studies support use of PUQE for quantifying pregnancy sickness,[4] and a separate validation study found that HELP identified indicators of severe disease.[5]
References
- [1] Nelson-Piercy C, Dean C, Shehmar M, et al. The management of nausea and vomiting in pregnancy and hyperemesis gravidarum: Green-top Guideline No. 69. BJOG. 2024. https://doi.org/10.1111/1471-0528.17739
- [2] Niemeijer MN, Grooten IJ, Vos N, et al. Diagnostic markers for hyperemesis gravidarum: a systematic review and meta-analysis. American Journal of Obstetrics and Gynecology. 2014;211(2):150.e1–150.e15. https://doi.org/10.1016/j.ajog.2014.02.012
- [3] Koot MH, Grooten IJ, Post JAMV, et al. Ketonuria is not associated with hyperemesis gravidarum disease severity. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2020;254:315–320. https://doi.org/10.1016/j.ejogrb.2020.08.014
- [4] Koren G, Piwko C, Ahn E, et al. Validation studies of the Pregnancy Unique-Quantification of Emesis (PUQE) scores. Journal of Obstetrics and Gynaecology. 2005;25(3):241–244. https://doi.org/10.1080/01443610500060651
- [5] MacGibbon KW, Kim S, Mullin PM, Fejzo MS. HyperEmesis Level Prediction (HELP Score) identifies patients with indicators of severe disease: a validation study. Geburtshilfe und Frauenheilkunde. 2021;81(1):90–98. https://doi.org/10.1055/a-1309-1997
What happens next—community, day care or hospital?
The right setting depends on your symptoms, hydration, weight loss, other health conditions, whether you can keep down medication and fluids, and how you have responded to treatment.
Community care
If you are able to drink and are not clinically dehydrated, care may begin with your GP, midwife or maternity team. This can include anti-sickness medication, advice about oral fluids and food, and follow-up. Treatment can still be appropriate even if your symptoms are described as mild or moderate.
Ambulatory or day-case care
If community treatment is not enough, or you cannot tolerate oral fluids or medication, you may be offered ambulatory care. This usually means attending hospital for assessment, fluids through a drip, vitamins including thiamine, and anti-sickness medication, then going home the same day if it is safe. Repeat visits may be arranged.
Inpatient care
An overnight hospital stay may be considered if you are clinically dehydrated, have lost more than 5% of your pre-pregnancy weight despite oral treatment, cannot keep down oral medication, have another condition that needs treatment, or remain unwell despite adequate ambulatory care. Admission decisions should be based on the whole clinical picture—not urine ketones alone.
Care is not yet consistent everywhere
Local pathways vary. Some hospitals have dedicated day-case services and others do not. If the care available near you differs from what is described here, that reflects real variation between services—not a failure on your part.
RCOG recommends anti-sickness treatment, reassurance, oral hydration and dietary advice in the community for people who are not dehydrated. Ambulatory day care is recommended when primary or community measures are unsuccessful or oral anti-sickness medication or fluids cannot be tolerated. It can provide intravenous fluids, vitamins and medication without an overnight stay. The guideline lists clinical circumstances in which inpatient care should be considered and explicitly states that ketonuria should not be used to assess severity.[1]
A randomised trial found that ambulatory treatment for severe nausea and vomiting in pregnancy was as effective as inpatient care for the study's primary outcome and was acceptable to patients, supporting day care as an option for appropriately selected patients.[2]
Provision is not uniform. A 2025 national service evaluation received responses from 129 of 139 maternity units in England, Scotland and Wales. Ambulatory management was available in 108 of 129 units (83.7%), while community treatment was reported by 19 of 128 responding units (14.8%). Routine screening at booking was reported by 37 of 129 units (28.7%). Despite the evidence, 69.5% of units still used ketonuria as an indication for admission.[3]
References
- [1] Nelson-Piercy C, Dean C, Shehmar M, et al. The management of nausea and vomiting in pregnancy and hyperemesis gravidarum: Green-top Guideline No. 69. BJOG. 2024. https://doi.org/10.1111/1471-0528.17739
- [2] Mitchell-Jones N, Farren JA, Tobias A, et al. Ambulatory versus inpatient management of severe nausea and vomiting of pregnancy: a randomised control trial with patient preference arm. BMJ Open. 2017;7:e017566. https://doi.org/10.1136/bmjopen-2017-017566
- [3] Nana M, Suff N, Gregori M, et al. How are hospitals in England, Scotland and Wales caring for women with nausea and vomiting in pregnancy: a national service evaluation. BMC Health Services Research. 2025;25:1128. https://doi.org/10.1186/s12913-025-12909-0